1. Robert A. Weinberg is at the Whitehead Institute for Biomedical Research, Ludwig Center for Molecular Oncology, MIT Department of Biology, Cambridge MA 02142, USA.
   e-mail: weinberg@wi.mit.edu

Abstract

The epithelial–mesenchymal transition (EMT) is a cellular transdifferentiation program that enables epithelial cancer cells to acquire traits of high-grade malignancy, notably invasive and metastatic powers. A new study indicates that it may also function early in tumour progression by preventing oncogene-induced senescence.

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