1. Margaret Frame is at the Edinburgh Cancer Research Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Crewe Road South, Edinburgh EH4 2XR.
   e-mail: m.frame@ed.ac.uk
2. Jim Norman is at the Beatson Institute for Cancer Research, Glasgow Garscube Estate, Switchback Road, Glasgow G61 1BD.
   e-mail: j.norman@beatson.gla.ac.uk

Abstract

Talin can activate integrins to bind the extracellular matrix and also connect matrix-engaged integrins to the actin cytoskeleton. New work shows that cell spreading can be dissected into three distinct phases according to their differential requirements for talin function.

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