News and Views
Nature Cell Biology 10, 1017 - 1019 (2008)
doi:10.1038/ncb0908-1017
A tal(in) of cell spreading
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Margaret Frame is at the Edinburgh Cancer Research Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Crewe Road South, Edinburgh EH4 2XR.
e-mail: m.frame@ed.ac.uk -
Jim Norman is at the Beatson Institute for Cancer Research, Glasgow Garscube Estate, Switchback Road, Glasgow G61 1BD.
e-mail: j.norman@beatson.gla.ac.uk
Abstract
Talin can activate integrins to bind the extracellular matrix and also connect matrix-engaged integrins to the actin cytoskeleton. New work shows that cell spreading can be dissected into three distinct phases according to their differential requirements for talin function.
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