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Letter

Nature Cell Biology 10, 971–978 (1 August 2008) | doi:10.1038/ncb1757

IQGAP3 regulates cell proliferation through the Ras/ERK signalling cascade

Hisashi Nojima , Makoto Adachi , Takeshi Matsui , Katsuya Okawa , Shoichiro Tsukita & Sachiko Tsukita

Proliferation of epithelial cells must be spatiotemporally regulated to maintain the organization of epithelial sheets. Here we show that the IQGAP family, comprising IQGAP1, 2 and 3, underlies lateral cell–cell contacts of epithelial cells.