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Nature Cell Biology 10, 883–885 (1 August 2008) | doi:10.1038/ncb0808-883
VE-cadherin and claudin-5: it takes two to tango
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Abstract
The formation of adhesive structures between adjacent cells, including adherens and tight junctions, contributes to the establishment of cell polarity, differentiation and survival, and is ultimately required for the maintenance of tissue integrity. Cadherins, the main constituent of adherens junctions, belong to a conserved family of adhesion molecules that provide a molecular bond between cells and link the plasma membrane with the intracellular actin cytoskeleton through catenin family proteins.
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