1. Jiri Bartek, Zdenek Hodny and Jiri Lukas are in the Institute of Cancer Biology and Centre for Genotoxic Stress Research, Danish Cancer Society, Copenhagen, Denmark, and in the Laboratory of Genome Integrity, Institute of Molecular Genetics, the Czech Academy of Sciences, Prague, Czech Republic.
   e-mail: jb@cancer.dk
   e-mail: hodny@img.cas.cz
   e-mail: jil@cancer.dk

Abstract

Cellular senescence, the permanent state of cell-cycle arrest, is emerging as an intrinsic barrier against tumorigenesis and a mechanism contributing to organismal ageing. Unexpected findings now identify multiple secreted inflammatory cytokines, their cognate receptors and positive-feedback loops with corresponding transcription factors, as key mediators of both oncogene-induced and replicative senescence.

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