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Nature Cell Biology 10, 885 - 887 (2008)
doi:10.1038/ncb0808-885
Golgi gets wired up
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Lennart Asp and Tommy Nilsson are in the Department of Medical Genetics, The Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.
e-mail: lennart.asp@gu.se
e-mail: tommy.nilsson@gu.se
Abstract
In endocrine cells, secretion can be rapidly upregulated in response to stimuli without the need for additional synthesis of transport components. A new and unexpected function of KDEL-R as a signalling receptor that senses cargo protein load in the early secretory pathway has been identified.
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