1. Julie Gavard is in the Institut Cochin, CNRS, UMR8104, INSERM, U567, Université Paris Descartes, 22 rue Méchain, 75014, Paris, France
   e-mail: julie.gavard@inserm.fr
2. J. Silvio Gutkind is in the Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Branch, National Institutes of Health, Bldg 30, Room 211, Bethesda MD20892, USA.
   e-mail: gutkind@dir.nidcr.nih.gov

Abstract

Endothelial barrier function requires the adhesive activity of VE-cadherin and claudin-5, which are key components of adherens and tight endothelial junctions, respectively. Emerging evidence suggests that VE-cadherin controls claudin-5 expression by preventing the nuclear accumulation of FoxO1 and -catenin, which repress the claudin-5 promoter. This indicates that a crosstalk mechanism operates between these junctional structures.

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