CNRS evolution sparks revolution - p875

doi:10.1038/ncb0808-875

At a time when change is necessary, French researchers are on the barricades resisting efforts to reform CNRS, the country's well respected basic research agency.

Full Text - CNRS evolution sparks revolution | PDF (214 KB) - CNRS evolution sparks revolution

Bringing models to life - p876

Pierre-François Lenne reviews Modeling Biology by Manfred D. Laublicher & Gerd B. Müller

doi:10.1038/ncb0808-876

Full Text - Bringing models to life | PDF (199 KB) - Bringing models to life

Twenty years of cell-cycle conferences in Roscoff - pp877 - 880

Isabelle Vernos & Jan-Michael Peters

doi:10.1038/ncb0808-877

Abstract - | Full Text - Twenty years of cell-cycle conferences in Roscoff | PDF (727 KB) - Twenty years of cell-cycle conferences in Roscoff

Nutrient sensing: TOR's Ragtime - pp881 - 883

Alfred J. Meijer & Patrice Codogno

doi:10.1038/ncb0808-881

The mammalian target of rapamycin (mTOR) controls cell growth and size. Amino acids are known to activate TOR, and Rag (Ras-related GTP-binding protein) GTPases have now been found to act as their effectors.

Full Text - Nutrient sensing: TOR's Ragtime | PDF (302 KB) - Nutrient sensing: TOR's Ragtime

VE-cadherin and claudin-5: it takes two to tango - pp883 - 885

Julie Gavard & J. Silvio Gutkind

doi:10.1038/ncb0808-883

Endothelial barrier function requires the adhesive activity of VE-cadherin and claudin-5, which are key components of adherens and tight endothelial junctions, respectively. Emerging evidence suggests that VE-cadherin controls claudin-5 expression by preventing the nuclear accumulation of FoxO1 and -catenin, which repress the claudin-5 promoter. This indicates that a crosstalk mechanism operates between these junctional structures.

Full Text - VE-cadherin and claudin-5: it takes two to tango | PDF (1,628 KB) - VE-cadherin and claudin-5: it takes two to tango

Golgi gets wired up - pp885 - 887

Lennart Asp & Tommy Nilsson

doi:10.1038/ncb0808-885

In endocrine cells, secretion can be rapidly upregulated in response to stimuli without the need for additional synthesis of transport components. A new and unexpected function of KDEL-R as a signalling receptor that senses cargo protein load in the early secretory pathway has been identified.

Full Text - Golgi gets wired up | PDF (339 KB) - Golgi gets wired up

Cytokine loops driving senescence - pp887 - 889

Jiri Bartek, Zdenek Hodny & Jiri Lukas

doi:10.1038/ncb0808-887

Cellular senescence, the permanent state of cell-cycle arrest, is emerging as an intrinsic barrier against tumorigenesis and a mechanism contributing to organismal ageing. Unexpected findings now identify multiple secreted inflammatory cytokines, their cognate receptors and positive-feedback loops with corresponding transcription factors, as key mediators of both oncogene-induced and replicative senescence.

Full Text - Cytokine loops driving senescence | PDF (388 KB) - Cytokine loops driving senescence

Research highlights - p890

doi:10.1038/ncb0808-890

Full Text - Research highlights | PDF (199 KB) - Research highlights

The regulated assembly of a PKC complex controls the completion of cytokinesis - pp891 - 901

Adrian T. Saurin, Joanne Durgan, Angus J. Cameron, Amir Faisal, Michael S. Marber & Peter J. Parker

doi:10.1038/ncb1749

Abstract - | Full Text - The regulated assembly of a PKC complex controls the completion of cytokinesis | PDF (2,434 KB) - The regulated assembly of a PKC complex controls the completion of cytokinesis | Supplementary information

EGFR signalling as a negative regulator of Notch1 gene transcription and function in proliferating keratinocytes and cancer - pp902 - 911

Vihren Kolev, Anna Mandinova, Juan Guinea-Viniegra, Bing Hu, Karine Lefort, Chiara Lambertini, Victor Neel, Reinhard Dummer, Erwin F. Wagner & G. Paolo Dotto

doi:10.1038/ncb1750

Abstract - | Full Text - EGFR signalling as a negative regulator of Notch1 gene transcription and function in proliferating keratinocytes and cancer | PDF (2,797 KB) - EGFR signalling as a negative regulator of Notch1 gene transcription and function in proliferating keratinocytes and cancer | Supplementary information

A traffic-activated Golgi-based signalling circuit coordinates the secretory pathway - pp912 - 922

Teodoro Pulvirenti, Monica Giannotta, Mariagrazia Capestrano, Mirco Capitani, Antonio Pisanu, Roman S. Polishchuk, Enrica San Pietro, Galina V. Beznoussenko, Alexander A. Mironov, Gabriele Turacchio, Victor W. Hsu, Michele Sallese & Alberto Luini

doi:10.1038/ncb1751

Abstract - | Full Text - A traffic-activated Golgi-based signalling circuit coordinates the secretory pathway | PDF (2,116 KB) - A traffic-activated Golgi-based signalling circuit coordinates the secretory pathway | Supplementary information

See also: News and Views by Asp & Nilsson

Endothelial adherens junctions control tight junctions by VE-cadherin-mediated upregulation of claudin-5 - pp923 - 934

Andrea Taddei, Costanza Giampietro, Annarita Conti, Fabrizio Orsenigo, Ferruccio Breviario, Valentina Pirazzoli, Michael Potente, Christopher Daly, Stefanie Dimmeler & Elisabetta Dejana

doi:10.1038/ncb1752

Abstract - | Full Text - Endothelial adherens junctions control tight junctions by VE-cadherin-mediated upregulation of claudin-5 | PDF (1,822 KB) - Endothelial adherens junctions control tight junctions by VE-cadherin-mediated upregulation of claudin-5 | Supplementary information

See also: News and Views by Gavard & Gutkind

Regulation of TORC1 by Rag GTPases in nutrient response - pp935 - 945

Eunjung Kim, Pankuri Goraksha-Hicks, Li Li, Thomas P. Neufeld & Kun-Liang Guan

doi:10.1038/ncb1753

Abstract - | Full Text - Regulation of TORC1 by Rag GTPases in nutrient response | PDF (1,894 KB) - Regulation of TORC1 by Rag GTPases in nutrient response | Supplementary information

See also: News and Views by Meijer & Codogno

The auxin influx carrier LAX3 promotes lateral root emergence - pp946 - 954

Kamal Swarup, Eva Benková, Ranjan Swarup, Ilda Casimiro, Benjamin Péret, Yaodong Yang, Geraint Parry, Erik Nielsen, Ive De Smet, Steffen Vanneste, Mitch P. Levesque, David Carrier, Nicholas James, Vanessa Calvo, Karin Ljung, Eric Kramer, Rebecca Roberts, Neil Graham, Sylvestre Marillonnet, Kanu Patel, Jonathan D.G. Jones, Christopher G. Taylor, Daniel P. Schachtman, Sean May, Goran Sandberg, Philip Benfey, Jiri Friml, Ian Kerr, Tom Beeckman, Laurent Laplaze & Malcolm J. Bennett

doi:10.1038/ncb1754

Abstract - | Full Text - The auxin influx carrier LAX3 promotes lateral root emergence | PDF (2,638 KB) - The auxin influx carrier LAX3 promotes lateral root emergence | Supplementary information

Actin restricts FcRI diffusion and facilitates antigen-induced receptor immobilization - pp955 - 963

Nicholas L. Andrews, Keith A. Lidke, Janet R. Pfeiffer, Alan R. Burns, Bridget S. Wilson, Janet M. Oliver & Diane S. Lidke

doi:10.1038/ncb1755

Abstract - | Full Text - Actin restricts FcRI diffusion and facilitates antigen-induced receptor immobilization | PDF (1,800 KB) - Actin restricts FcRI diffusion and facilitates antigen-induced receptor immobilization | Supplementary information

Modulation of intracellular trafficking regulates cell intercalation in the Drosophila trachea - pp964 - 970

Daniel D. Shaye, Jordi Casanova & Marta Llimargas

doi:10.1038/ncb1756

First Paragraph - | Full Text - Modulation of intracellular trafficking regulates cell intercalation in the Drosophila trachea | PDF (2,330 KB) - Modulation of intracellular trafficking regulates cell intercalation in the Drosophila trachea | Supplementary information

IQGAP3 regulates cell proliferation through the Ras/ERK signalling cascade - pp971 - 978

Hisashi Nojima, Makoto Adachi, Takeshi Matsui, Katsuya Okawa, Shoichiro Tsukita & Sachiko Tsukita

doi:10.1038/ncb1757

First Paragraph - | Full Text - IQGAP3 regulates cell proliferation through the Ras/ERK signalling cascade | PDF (2,045 KB) - IQGAP3 regulates cell proliferation through the Ras/ERK signalling cascade | Supplementary information

EphrinB1 controls cell–cell junctions through the Par polarity complex - pp979 - 986

Hyun-Shik Lee, Tagvor G. Nishanian, Kathleen Mood, Yong-Sik Bong & Ira O. Daar

doi:10.1038/ncb1758

First Paragraph - | Full Text - EphrinB1 controls cell–cell junctions through the Par polarity complex | PDF (1,483 KB) - EphrinB1 controls cell–cell junctions through the Par polarity complex | Supplementary information

A feedback loop comprising lin-28 and let-7 controls pre-let-7 maturation during neural stem-cell commitment - pp987 - 993

Agnieszka Rybak, Heiko Fuchs, Lena Smirnova, Christine Brandt, Elena E. Pohl, Robert Nitsch & F. Gregory Wulczyn

doi:10.1038/ncb1759

First Paragraph - | Full Text - A feedback loop comprising lin-28 and let-7 controls pre-let-7 maturation during neural stem-cell commitment | PDF (1,185 KB) - A feedback loop comprising lin-28 and let-7 controls pre-let-7 maturation during neural stem-cell commitment | Supplementary information

Targeting WW domains linker of HECT-type ubiquitin ligase Smurf1 for activation by CKIP-1 - pp994 - 1002

Kefeng Lu, Xiushan Yin, Tujun Weng, Shenli Xi, Li Li, Guichun Xing, Xuan Cheng, Xiao Yang, Lingqiang Zhang & Fuchu He

doi:10.1038/ncb1760

First Paragraph - | Full Text - Targeting WW domains linker of HECT-type ubiquitin ligase Smurf1 for activation by CKIP-1 | PDF (1,933 KB) - Targeting WW domains linker of HECT-type ubiquitin ligase Smurf1 for activation by CKIP-1 | Supplementary information

Epidermal JunB represses G-CSF transcription and affects haematopoiesis and bone formation - pp1003 - 1011

Arabella Meixner, Rainer Zenz, Helia B Schonthaler, Lukas Kenner, Harald Scheuch, Josef M. Penninger & Erwin F. Wagner

doi:10.1038/ncb1761

First Paragraph - | Full Text - Epidermal JunB represses G-CSF transcription and affects haematopoiesis and bone formation | PDF (2,331 KB) - Epidermal JunB represses G-CSF transcription and affects haematopoiesis and bone formation | Supplementary information

Erratum - p1012

doi:10.1038/ncb0808-1012

Full Text - Erratum | PDF (118 KB) - Erratum