Birthday precedings - p753

doi:10.1038/ncb0708-753a

As some of the new 'web 2.0'-enabled publishing ventures mature, we take stock of their utility to the community

Full Text - Birthday precedings | PDF (217 KB) - Birthday precedings

Signalling links - p753

doi:10.1038/ncb0708-753b

Our papers now link directly to relevant Molecule Page database entries at the Signaling Gateway

Full Text - Signalling links | PDF (183 KB) - Signalling links

Cdh1: a master G0/G1 regulator - pp755 - 757

Jeffrey R. Skaar & Michele Pagano

doi:10.1038/ncb0708-755

APC/C^Cdh1 controls the G0 and G1 phases of the cell cycle. Using a conditional knockout of the Cdh1 coding gene Fizzy-related (Fzr), a new study demonstrates that Cdh1 is essential for viability and that it functions as a tumour suppressor by preventing genomic instability.

Full Text - Cdh1: a master G0/G1 regulator | PDF (441 KB) - Cdh1: a master G0/G1 regulator

See also: Article by García-Higuera et al.

Breaking down EMT - pp757 - 759

Romain Levayer & Thomas Lecuit

doi:10.1038/ncb0708-757

Epithelial–mesenchymal transition, in which epithelial cells lose their polarity and become motile mesenchymal cells, occurs during development and marks a key step in tumour progression towards metastasis. Most studies of this process have focused on the disassembly of adherens junctions, but regulation of basement membrane breakdown by a pathway involving RhoA and microtubules may be equally important.

Full Text - Breaking down EMT | PDF (515 KB) - Breaking down EMT

See also: Article by Nakaya et al.

UVRAG reveals its second nature - pp759 - 761

Karolina Peplowska, Margarita Cabrera & Christian Ungermann

doi:10.1038/ncb0708-759

UVRAG, a known regulator of autophagosome formation, also promotes autophagosome maturation by recruiting the fusion machinery of the late endosome.

Full Text - UVRAG reveals its second nature | PDF (369 KB) - UVRAG reveals its second nature

See also: Article by Liang et al.

Opposing roles for glypicans in Hedgehog signalling - pp761 - 763

Dong Yan & Xinhua Lin

doi:10.1038/ncb0708-761

Glypican members of the heparan sulphate proteoglycan family regulate several developmental signalling pathways, such as those involving Hedgehog, Wnt, BMP and FGF. Two studies reveal opposite effects of glypicans on Hedgehog signalling and show how their core protein domains and GPI anchor contribute to their versatile biological functions.

Full Text - Opposing roles for glypicans in Hedgehog signalling | PDF (401 KB) - Opposing roles for glypicans in Hedgehog signalling

Research highlights - p764

doi:10.1038/ncb0708-764

Full Text - Research highlights | PDF (178 KB) - Research highlights

RhoA and microtubule dynamics control cell–basement membrane interaction in EMT during gastrulation - pp765 - 775

Yukiko Nakaya, Erike W. Sukowati, Yuping Wu & Guojun Sheng

doi:10.1038/ncb1739

Abstract - | Full Text - RhoA and microtubule dynamics control cell–basement membrane interaction in EMT during gastrulation | PDF (3,964 KB) - RhoA and microtubule dynamics control cell–basement membrane interaction in EMT during gastrulation | Supplementary information

See also: News and Views by Levayer & Lecuit

Beclin1-binding UVRAG targets the class C Vps complex to coordinate autophagosome maturation and endocytic trafficking - pp776 - 787

Chengyu Liang, Jong-soo Lee, Kyung-Soo Inn, Michaela U. Gack, Qinglin Li, Esteban A. Roberts, Isabelle Vergne, Vojo Deretic, Pinghui Feng, Chihiro Akazawa & Jae U. Jung

doi:10.1038/ncb1740

Abstract - | Full Text - Beclin1-binding UVRAG targets the class C Vps complex to coordinate autophagosome maturation and endocytic trafficking | PDF (2,493 KB) - Beclin1-binding UVRAG targets the class C Vps complex to coordinate autophagosome maturation and endocytic trafficking | Supplementary information

See also: News and Views by Peplowska et al.

A three-step pathway comprising PLZF/miR-146a/CXCR4 controls megakaryopoiesis - pp788 - 801

Catherine Labbaye, Isabella Spinello, Maria Teresa Quaranta, Elvira Pelosi, Luca Pasquini, Eleonora Petrucci, Mauro Biffoni, Eugenia Rosa Nuzzolo, Monia Billi, Robin Foà, Ercole Brunetti, Francesco Grignani, Ugo Testa & Cesare Peschle

doi:10.1038/ncb1741

Abstract - | Full Text - A three-step pathway comprising PLZF/miR-146a/CXCR4 controls megakaryopoiesis | PDF (1,796 KB) - A three-step pathway comprising PLZF/miR-146a/CXCR4 controls megakaryopoiesis | Supplementary information

Genomic stability and tumour suppression by the APC/C cofactor Cdh1 - pp802 - 811

Irene García-Higuera, Eusebio Manchado, Pierre Dubus, Marta Cañamero, Juan Méndez, Sergio Moreno & Marcos Malumbres

doi:10.1038/ncb1742

Abstract - | Full Text - Genomic stability and tumour suppression by the APC/C cofactor Cdh1 | PDF (2,143 KB) - Genomic stability and tumour suppression by the APC/C cofactor Cdh1 | Supplementary information

See also: News and Views by Skaar & Pagano

Control of HIPK2 stability by ubiquitin ligase Siah-1 and checkpoint kinases ATM and ATR - pp812 - 824

Melanie Winter, Dirk Sombroek, Ilka Dauth, Jutta Moehlenbrink, Karin Scheuermann, Johanna Crone & Thomas G. Hofmann

doi:10.1038/ncb1743

Abstract - | Full Text - Control of HIPK2 stability by ubiquitin ligase Siah-1 and checkpoint kinases ATM and ATR | PDF (2,664 KB) - Control of HIPK2 stability by ubiquitin ligase Siah-1 and checkpoint kinases ATM and ATR | Supplementary information

Opposing roles for p16^Ink4a and p19^Arf in senescence and ageing caused by BubR1 insufficiency - pp825 - 836

Darren J. Baker, Carmen Perez-Terzic, Fang Jin, Kevin Pitel, Nicolas J. Niederländer, Karthik Jeganathan, Satsuki Yamada, Santiago Reyes, Lois Rowe, H. Jay Hiddinga, Norman L. Eberhardt, Andre Terzic & Jan M. van Deursen

doi:10.1038/ncb1744

Abstract - | Full Text - Opposing roles for p16Ink4a and p19Arf in senescence and ageing caused by BubR1 insufficiency | PDF (2,202 KB) - Opposing roles for p16Ink4a and p19Arf in senescence and ageing caused by BubR1 insufficiency | Supplementary information

TAZ controls Smad nucleocytoplasmic shuttling and regulates human embryonic stem-cell self-renewal - pp837 - 848

Xaralabos Varelas, Rui Sakuma, Payman Samavarchi-Tehrani, Raheem Peerani, Balaji M. Rao, Joanna Dembowy, Michael B. Yaffe, Peter W. Zandstra & Jeffrey L. Wrana

doi:10.1038/ncb1748

Abstract - | Full Text - TAZ controls Smad nucleocytoplasmic shuttling and regulates human embryonic stem-cell self-renewal | PDF (2,611 KB) - TAZ controls Smad nucleocytoplasmic shuttling and regulates human embryonic stem-cell self-renewal | Supplementary information

WAVE and Arp2/3 jointly inhibit filopodium formation by entering into a complex with mDia2 - pp849 - 857

Petra Beli, Debora Mascheroni, Dalu Xu & Metello Innocenti

doi:10.1038/ncb1745

First Paragraph - | Full Text - WAVE and Arp2/3 jointly inhibit filopodium formation by entering into a complex with mDia2 | PDF (1,925 KB) - WAVE and Arp2/3 jointly inhibit filopodium formation by entering into a complex with mDia2 | Supplementary information

Spindle-localized CPE-mediated translation controls meiotic chromosome segregation - pp858 - 865

Carolina Eliscovich, Isabel Peset, Isabelle Vernos & Raúl Méndez

doi:10.1038/ncb1746

First Paragraph - | Full Text - Spindle-localized CPE-mediated translation controls meiotic chromosome segregation | PDF (1,432 KB) - Spindle-localized CPE-mediated translation controls meiotic chromosome segregation | Supplementary information

Nitric oxide-induced nuclear GAPDH activates p300/CBP and mediates apoptosis - pp866 - 873

Nilkantha Sen, Makoto R. Hara, Michael D. Kornberg, Matthew B. Cascio, Byoung-Il Bae, Neelam Shahani, Bobby Thomas, Ted M. Dawson, Valina L. Dawson, Solomon H. Snyder & Akira Sawa

doi:10.1038/ncb1747

First Paragraph - | Full Text - Nitric oxide-induced nuclear GAPDH activates p300/CBP and mediates apoptosis | PDF (1,269 KB) - Nitric oxide-induced nuclear GAPDH activates p300/CBP and mediates apoptosis | Supplementary information

Erratum - p874

doi:10.1038/ncb0708-874

Full Text - Erratum | PDF (238 KB) - Erratum