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Nature Cell Biology 10, 761–763 (1 July 2008) | doi:10.1038/ncb0708-761
Opposing roles for glypicans in Hedgehog signalling
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Abstract
Heparan sulphate proteoglycans (HSPGs) are cell surface and extracellular matrix proteins that are expressed in most, if not all, animal cells. They are composed of a protein core to which heparan sulphate glycosaminoglycan (GAG) chains are attached.
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