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Nature Cell Biology 10, 755–757 (1 July 2008) | doi:10.1038/ncb0708-755
Cdh1: a master G0/G1 regulator
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Abstract
The timely and unidirectional progression of the cell cycle is controlled by ubiquitin-mediated proteolysis of core components of the cell-cycle machinery. Two ubiquitin ligase complexes in particular, SCF (Skp1/CUL1/F-box protein) and APC/C (Anaphase Promoting Complex/Cyclosome), control the ubiquitination and subsequent degradation of many key cell-cycle regulators, with SCF-based ligases being active throughout the cell cycle and APC/C being active from mitosis to late G1 (refs 1,2).
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