News and Views
Nature Cell Biology 10, 761 - 763 (2008)
doi:10.1038/ncb0708-761
Opposing roles for glypicans in Hedgehog signalling
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Dong Yan and Xinhua Lin are in the Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
e-mail: xinhua.lin@cchmc.org
Abstract
Glypican members of the heparan sulphate proteoglycan family regulate several developmental signalling pathways, such as those involving Hedgehog, Wnt, BMP and FGF. Two studies reveal opposite effects of glypicans on Hedgehog signalling and show how their core protein domains and GPI anchor contribute to their versatile biological functions.
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