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Letter

Nature Cell Biology 10, 731–739 (1 June 2008) | doi:10.1038/ncb1736

Nanog and Oct4 associate with unique transcriptional repression complexes in embryonic stem cells

Jiancong Liang , Ma Wan , Yi Zhang , Peili Gu , Huawei Xin , Sung Yun Jung , Jun Qin , Jiemin Wong , Austin J. Cooney , Dan Liu & Zhou Songyang

Nanog and Oct4 are essential transcription factors that regulate self-renewal and pluripotency of ES cells. However, the mechanisms by which Nanog and Oct4 modulate ES cell fate remain unknown.