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Letter
Nature Cell Biology 10, 723–730 (1 June 2008) | doi:10.1038/ncb1735
p53-Driven apoptosis limits centrosome amplification and genomic instability downstream of NPM1 phosphorylation
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Abstract
Chromosome loss or gain is associated with a large number of solid cancers, providing genomic plasticity and thus adaptability to cancer cells. Numerical centrosome abnormalities arising from centrosome over-duplication or failed cytokinesis are a recognized cause of aneuploidy.
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