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Letter

Nature Cell Biology 10, 698–706 (1 June 2008) | doi:10.1038/ncb1732

Netrin-1 mediates neuronal survival through PIKE-L interaction with the dependence receptor UNC5B

Xiaoling Tang , Sung-Wuk Jang , Masashi Okada , Chi-Bun Chan , Yue Feng , Yu Liu , Shi-Wen Luo , Yan Hong , Nicolas Rama , Wen-Cheng Xiong , Patrick Mehlen & Keqiang Ye

Netrins, a family of secreted molecules, have critical functions in axon guidance and cell migration during neuronal development. In addition to its role as a chemotropic molecule, netrin-1 also acts as a survival factor.