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Nature Cell Biology 10, 639 - 641 (2008)
doi:10.1038/ncb0608-639

Skeletal muscle dressed in SOCs

Dong Min Shin1 & Shmuel Muallem2

  1. Dong Min Shin is in the Department of Oral Biology, Yonsei University College of Dentistry, Seoul 120-752, Korea.
  2. Shmuel Muallem is in the Department of Physiology, University of Texas Southwestern Medical Center, Dallas, Texas, 75235-9040, USA.
    e-mail: shmuel.muallem@utsouthwestern.edu

Store-operated Ca2+ channels (SOCs) are activated in response to Ca2+ release from the endoplasmic reticulum (ER). The stromal interaction molecule 1 (STIM1) is the ER sensor that transmits the stored Ca2+ content to the pore-forming SOCs Orai and TRPC channels. Recent studies reveal high levels of Orai1 and STIM1 in skeletal muscle, and a prominent role of SOCs in muscle development and function.

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