1. Kohei Miyazono, Yuto Kamiya and Keiji Miyazawa are in the Department of Molecular Pathology, Graduate School of Medicine, University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033, Japan.
   e-mail: miyazono-ind@umin.ac.jp
   e-mail: mm66211@mail.ecc.u-tokyo.ac.jp
   e-mail: keiji-miyazawa@umin.ac.jp

Abstract

Transforming growth factor- (TGF-) stimulates phosphorylation of TGF- type I receptor. This receptor is now shown to be sumoylated, leading to enhanced activation and modulation of the downstream Smad signalling pathway.

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