Access

Letter

Nature Cell Biology 10, 593–601 (1 May 2008) | doi:10.1038/ncb1722

The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1

Philip A. Gregory , Andrew G. Bert , Emily L. Paterson , Simon C. Barry , Anna Tsykin , Gelareh Farshid , Mathew A. Vadas , Yeesim Khew-Goodall & Gregory J. Goodall

Epithelial to mesenchymal transition (EMT) facilitates tissue remodelling during embryonic development and is viewed as an essential early step in tumour metastasis. We found that all five members of the microRNA-200 family (miR-200a, miR-200b, miR-200c, miR-141 and miR-429) and miR-205 were markedly downregulated in cells that had undergone EMT in response to transforming growth factor (TGF)-β or to ectopic expression of the protein tyrosine phosphatase Pez.