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Letter

Nature Cell Biology 10, 567–574 (1 May 2008) | doi:10.1038/ncb1719

A crucial role of a high mobility group protein HMGA2 in cardiogenesis

Koshiro Monzen , Yuzuru Ito , Atsuhiko T. Naito , Hiroki Kasai , Yukio Hiroi , Doubun Hayashi , Ichiro Shiojima , Tsutomu Yamazaki , Kohei Miyazono , Makoto Asashima , Ryozo Nagai & Issei Komuro

The high mobility group (HMG) of nuclear proteins regulates expression of many genes through architectural remodelling of the chromatin structure, and formation of multiprotein complexes on promoter/enhancer regions. This leads to the active transcription of their target genes.