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Starved cells eat ribosomes

Autophagy is a process in which cytoplasmic components are broken down to supply materials for the synthesis of essential molecules under nutrient-limiting conditions. Because this process involves random sequestration of the cytoplasm by large membrane vesicles, considerable amounts of molecules, such as ribosomes, are necessarily degraded by autophagy. However, starving cells also promote additional selective degradation of ribosomes as a requirement for survival.

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Figure 1: Schematic diagram of autophagic degradation of ribosomes in yeast.

References

  1. Mizushima, N. Genes Dev. 21, 2861–2873 (2007).

    Article  CAS  Google Scholar 

  2. Xie, Z. & Klionsky, D. J. Nature Cell Biol. 9, 1102–1109 (2007).

    Article  CAS  Google Scholar 

  3. Onodera, J. & Ohsumi, Y. J. Biol. Chem. 280, 31582–31586 (2005).

    Article  CAS  Google Scholar 

  4. Takeshige, K. et al. J. Cell Biol. 119, 301–311 (1992).

    Article  CAS  Google Scholar 

  5. Kraft, C. et al. Nature Cell Biol. 10, 602–610 (2008).

    Article  CAS  Google Scholar 

  6. Scott, S. V., Baba, M., Ohsumi, Y. & Klionsky, D. J. J. Cell Biol. 138, 37–44 (1997).

    Article  CAS  Google Scholar 

  7. Baba, M. et al. J. Cell Biol. 139, 1687–1695 (1997).

    Article  CAS  Google Scholar 

  8. Scott, S. V. et al. Mol. Cell 7, 1131–1141 (2001).

    Article  CAS  Google Scholar 

  9. Bjorkoy, G. et al. J. Cell Biol. 171, 603–614 (2005).

    Article  Google Scholar 

  10. Komatsu, M. et al. Cell 131, 1149–1163 (2007).

    Article  CAS  Google Scholar 

  11. Onodera, J. & Ohsumi, Y. J. Biol. Chem. 279, 16071–16076 (2004).

    Article  CAS  Google Scholar 

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Nakatogawa, H., Ohsumi, Y. Starved cells eat ribosomes. Nat Cell Biol 10, 505–507 (2008). https://doi.org/10.1038/ncb0508-505

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