News and Views
Nature Cell Biology 10, 501 - 502 (2008)
doi:10.1038/ncb0508-501
MicroRNAs — keeping cells in formation
Eric A. Miska1
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Eric A. Miska is at the Wellcome Trust/Cancer Research UK Gurdon Institute and Department of Biochemistry, University of Cambridge, Cambridge CB2 1QN, UK.
e-mail: eam29@cam.ac.uk
Abstract
During epithelial–mesenchymal transition (EMT) cells loosen their intercellular contacts and leave the epithelial layer. Three microRNA (miRNA) families modulate EMT upstream of the key cell-adhesion protein E-cadherin, highlighting the potential importance of miRNAs in EMT-dependent processes, such as mesoderm development and tumour metastasis.
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