Changing gear - p499

doi:10.1038/ncb0508-499

Is scientific progress being stifled by a lack of support for researchers who aim to change research directions?

Full Text - Changing gear | PDF (270 KB) - Changing gear

MicroRNAs — keeping cells in formation - pp501 - 502

Eric A. Miska

doi:10.1038/ncb0508-501

During epithelial–mesenchymal transition (EMT) cells loosen their intercellular contacts and leave the epithelial layer. Three microRNA (miRNA) families modulate EMT upstream of the key cell-adhesion protein E-cadherin, highlighting the potential importance of miRNAs in EMT-dependent processes, such as mesoderm development and tumour metastasis.

Full Text - MicroRNAs — keeping cells in formation | PDF (330 KB) - MicroRNAs — keeping cells in formation

Inflammation as a matchmaker: revisiting cell fusion - pp503 - 505

Ilyas Singec & Evan Y. Snyder

doi:10.1038/ncb0508-503

Sporadic fusion of bone-marrow-derived cells with those of developmentally unrelated structures following transplantation has previously been regarded solely as an artefact, leading to the misinterpretation that cells could 'transdifferentiate'. We now learn that heterotypic cell fusion of myelo-lymphoid cells with non-haematopoietic cells is enhanced during chronic inflammation, raising new questions about the biological significance of this controversial phenomenon.

Full Text - Inflammation as a matchmaker: revisiting cell fusion | PDF (438 KB) - Inflammation as a matchmaker: revisiting cell fusion

See also: Letter by Johansson et al. | Letter by Nygren et al.

Starved cells eat ribosomes - pp505 - 507

Hitoshi Nakatogawa & Yoshinori Ohsumi

doi:10.1038/ncb0508-505

Autophagy is a process in which cytoplasmic components are broken down to supply materials for the synthesis of essential molecules under nutrient-limiting conditions. Because this process involves random sequestration of the cytoplasm by large membrane vesicles, considerable amounts of molecules, such as ribosomes, are necessarily degraded by autophagy. However, starving cells also promote additional selective degradation of ribosomes as a requirement for survival.

Full Text - Starved cells eat ribosomes | PDF (597 KB) - Starved cells eat ribosomes

See also: Letter by Kraft et al.

Marked for death - pp507 - 509

Kevin Petrie & Arthur Zelent

doi:10.1038/ncb0508-507

SUMOylation of PML–RAR oncoprotein has been linked to its arsenic-induced degradation and the therapeutic response in acute promyelocytic leukaemia. Two groups identify PML as an in vivo target of the RING finger ubiquitin E3 ligase RNF4, which specifically binds polySUMOylated PML and is essential for the arsenic-induced catabolism of both PML and PML–RAR.

Full Text - Marked for death | PDF (509 KB) - Marked for death

See also: Article by Tatham et al. | Article by Lallemand-Breitenbach et al.

Coming closer to a stoma ion channel - pp509 - 511

Laura Serna

doi:10.1038/ncb0508-509

Plant stomata, which consist of paired guard cells placed on the surface of leaves, control gas exchange with the atmosphere. Anion transport by unidentified guard-cell channels closes the stomatal pore and the first component for this channel function has now been found.

Full Text - Coming closer to a stoma ion channel | PDF (340 KB) - Coming closer to a stoma ion channel

RanBP2 resolves sister centromeres - p512

Silvia Grisendi

doi:10.1038/ncb0508-512

Full Text - RanBP2 resolves sister centromeres | PDF (223 KB) - RanBP2 resolves sister centromeres

Differential function of Tie2 at cell–cell contacts and cell–substratum contacts regulated by angiopoietin-1 - pp513 - 526

Shigetomo Fukuhara, Keisuke Sako, Takashi Minami, Kazuomi Noda, Hak Zoo Kim, Tatsuhiko Kodama, Masabumi Shibuya, Nobuyuki Takakura, Gou Young Koh & Naoki Mochizuki

doi:10.1038/ncb1714

Abstract - | Full Text - Differential function of Tie2 at cell–cell contacts and cell–substratum contacts regulated by angiopoietin-1 | PDF (4,055 KB) - Differential function of Tie2 at cell–cell contacts and cell–substratum contacts regulated by angiopoietin-1 | Supplementary information

Angiopoietins assemble distinct Tie2 signalling complexes in endothelial cell–cell and cell–matrix contacts - pp527 - 537

Pipsa Saharinen, Lauri Eklund, Juho Miettinen, Riikka Wirkkala, Andrey Anisimov, Mark Winderlich, Astrid Nottebaum, Dietmar Vestweber, Urban Deutsch, Gou Young Koh, Bjorn R. Olsen & Kari Alitalo

doi:10.1038/ncb1715

Abstract - | Full Text - Angiopoietins assemble distinct Tie2 signalling complexes in endothelial cell–cell and cell–matrix contacts | PDF (9,763 KB) - Angiopoietins assemble distinct Tie2 signalling complexes in endothelial cell–cell and cell–matrix contacts | Supplementary information

RNF4 is a poly-SUMO-specific E3 ubiquitin ligase required for arsenic-induced PML degradation - pp538 - 546

Michael H. Tatham, Marie-Claude Geoffroy, Linnan Shen, Anna Plechanovova, Neil Hattersley, Ellis G. Jaffray, Jorma J. Palvimo & Ronald T. Hay

doi:10.1038/ncb1716

Abstract - | Full Text - RNF4 is a poly-SUMO-specific E3 ubiquitin ligase required for arsenic-induced PML degradation | PDF (1,805 KB) - RNF4 is a poly-SUMO-specific E3 ubiquitin ligase required for arsenic-induced PML degradation | Supplementary information

See also: News and Views by Petrie & Zelent

Arsenic degrades PML or PML–RAR through a SUMO-triggered RNF4/ubiquitin-mediated pathway - pp547 - 555

Valérie Lallemand-Breitenbach, Marion Jeanne, Shirine Benhenda, Rihab Nasr, Ming Lei, Laurent Peres, Jun Zhou, Jun Zhu, Brian Raught & Hugues de Thé

doi:10.1038/ncb1717

Abstract - | Full Text - Arsenic degrades PML or PML–RAR through a SUMO-triggered RNF4/ubiquitin-mediated pathway | PDF (1,977 KB) - Arsenic degrades PML or PML–RAR through a SUMO-triggered RNF4/ubiquitin-mediated pathway | Supplementary information

See also: News and Views by Petrie & Zelent

A pathway for phagosome maturation during engulfment of apoptotic cells - pp556 - 566

Jason M. Kinchen, Kimon Doukoumetzidis, Johann Almendinger, Lilli Stergiou, Annie Tosello-Trampont, Costi D. Sifri, Michael O. Hengartner & Kodi S. Ravichandran

doi:10.1038/ncb1718

First Paragraph - | Full Text - A pathway for phagosome maturation during engulfment of apoptotic cells | PDF (2,183 KB) - A pathway for phagosome maturation during engulfment of apoptotic cells | Supplementary information

A crucial role of a high mobility group protein HMGA2 in cardiogenesis - pp567 - 574

Koshiro Monzen, Yuzuru Ito, Atsuhiko T. Naito, Hiroki Kasai, Yukio Hiroi, Doubun Hayashi, Ichiro Shiojima, Tsutomu Yamazaki, Kohei Miyazono, Makoto Asashima, Ryozo Nagai & Issei Komuro

doi:10.1038/ncb1719

First Paragraph - | Full Text - A crucial role of a high mobility group protein HMGA2 in cardiogenesis | PDF (1,487 KB) - A crucial role of a high mobility group protein HMGA2 in cardiogenesis | Supplementary information

Extensive fusion of haematopoietic cells with Purkinje neurons in response to chronic inflammation - pp575 - 583

Clas B. Johansson, Sawsan Youssef, Kassie Koleckar, Colin Holbrook, Regis Doyonnas, Stephane Y. Corbel, Lawrence Steinman, Fabio M. V. Rossi & Helen M. Blau

doi:10.1038/ncb1720

First Paragraph - | Full Text - Extensive fusion of haematopoietic cells with Purkinje neurons in response to chronic inflammation | PDF (1,850 KB) - Extensive fusion of haematopoietic cells with Purkinje neurons in response to chronic inflammation | Supplementary information

See also: News and Views by Singec & Snyder

Myeloid and lymphoid contribution to non-haematopoietic lineages through irradiation-induced heterotypic cell fusion - pp584 - 592

Jens M. Nygren, Karina Liuba, Martin Breitbach, Simon Stott, Lina Thorén, Wilhelm Roell, Caroline Geisen, Philipp Sasse, Deniz Kirik, Anders Björklund, Claus Nerlov, Bernd K. Fleischmann, Stefan Jovinge & Sten Eirik W. Jacobsen

doi:10.1038/ncb1721

First Paragraph - | Full Text - Myeloid and lymphoid contribution to non-haematopoietic lineages through irradiation-induced heterotypic cell fusion | PDF (1,668 KB) - Myeloid and lymphoid contribution to non-haematopoietic lineages through irradiation-induced heterotypic cell fusion | Supplementary information

See also: News and Views by Singec & Snyder

The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1 - pp593 - 601

Philip A. Gregory, Andrew G. Bert, Emily L. Paterson, Simon C. Barry, Anna Tsykin, Gelareh Farshid, Mathew A. Vadas, Yeesim Khew-Goodall & Gregory J. Goodall

doi:10.1038/ncb1722

First Paragraph - | Full Text - The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1 | PDF (1,819 KB) - The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1 | Supplementary information

See also: News and Views by Miska

Mature ribosomes are selectively degraded upon starvation by an autophagy pathway requiring the Ubp3p/Bre5p ubiquitin protease - pp602 - 610

Claudine Kraft, Anna Deplazes, Marc Sohrmann & Matthias Peter

doi:10.1038/ncb1723

First Paragraph - | Full Text - Mature ribosomes are selectively degraded upon starvation by an autophagy pathway requiring the Ubp3p/Bre5p ubiquitin protease | PDF (1,977 KB) - Mature ribosomes are selectively degraded upon starvation by an autophagy pathway requiring the Ubp3p/Bre5p ubiquitin protease | Supplementary information

See also: News and Views by Nakatogawa & Ohsumi

p53 regulates glucose metabolism through an IKK-NF-B pathway and inhibits cell transformation - pp611 - 618

Keiko Kawauchi, Keigo Araki, Kei Tobiume & Nobuyuki Tanaka

doi:10.1038/ncb1724

First Paragraph - | Full Text - p53 regulates glucose metabolism through an IKK-NF-B pathway and inhibits cell transformation | PDF (1,446 KB) - p53 regulates glucose metabolism through an IKK-NF-B pathway and inhibits cell transformation | Supplementary information

Intercellular transfer of the oncogenic receptor EGFRvIII by microvesicles derived from tumour cells - pp619 - 624

Khalid Al-Nedawi, Brian Meehan, Johann Micallef, Vladimir Lhotak, Linda May, Abhijit Guha & Janusz Rak

doi:10.1038/ncb1725

First Paragraph - | Full Text - Intercellular transfer of the oncogenic receptor EGFRvIII by microvesicles derived from tumour cells | PDF (1,139 KB) - Intercellular transfer of the oncogenic receptor EGFRvIII by microvesicles derived from tumour cells | Supplementary information

Root growth in Arabidopsis requires gibberellin/DELLA signalling in the endodermis - pp625 - 628

Susana Ubeda-Tomás, Ranjan Swarup, Juliet Coates, Kamal Swarup, Laurent Laplaze, Gerrit T.S. Beemster, Peter Hedden, Rishikesh Bhalerao & Malcolm J. Bennett

doi:10.1038/ncb1726

Abstract - | Full Text - Root growth in Arabidopsis requires gibberellin/DELLA signalling in the endodermis | PDF (906 KB) - Root growth in Arabidopsis requires gibberellin/DELLA signalling in the endodermis | Supplementary information