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Nature Cell Biology 10, 377–379 (1 April 2008) | doi:10.1038/ncb0408-377
BRCA1 and stem cells: tumour typecasting
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Abstract
The ducts and lobules of the human breast are made up of two morphologically distinct cell populations: the inner, milk producing luminal epithelial cells, which express low molecular-weight cytokeratins and the oestrogen receptor (ER), and the outer, supporting basal myoepithelial cells, which express high molecular-weight cytokeratins and smooth muscle markers. There is considerable evidence for a differentiation hierarchy within the breast (Fig.
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