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Letter

Nature Cell Biology 10, 489–496 (1 April 2008) | doi:10.1038/ncb1713

Drosophila STAT is required for directly maintaining HP1 localization and heterochromatin stability

Song Shi , Kimberly Larson , Dongdong Guo , Su Jun Lim , Pranabananda Dutta , Shian-Jang Yan & Willis X. Li

STAT (Signal transducer and activator of transcription) is a potent transcription factor and its aberrant activation by phosphorylation is associated with human cancers. We have shown previously that overactivation of JAK, which phosphorylates STAT, disrupts heterochromatin formation globally in Drosophila melanogaster.