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Letter
Nature Cell Biology 10, 476–482 (1 April 2008) | doi:10.1038/ncb1711
A bistable Rb|[ndash]|E2F switch underlies the restriction point
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Abstract
The restriction point (R-point) marks the critical event when a mammalian cell commits to proliferation and becomes independent of growth stimulation. It is fundamental for normal differentiation and tissue homeostasis, and seems to be dysregulated in virtually all cancers.
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