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Letter

Nature Cell Biology 10, 445–451 (1 April 2008) | doi:10.1038/ncb1707

Securin regulates entry into M-phase by modulating the stability of cyclin B

Petros Marangos & John Carroll

Timely progression into mitosis is necessary for normal cell division. This transition is sensitive to the levels of cyclin B, the regulatory subunit of the master mitotic kinase, Cdk1.