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Nature Cell Biology 10, 381–383 (1 April 2008) | doi:10.1038/ncb0408-381
Securin' M-phase entry
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Abstract
The APC is a large ubiquitin ligase that promotes the degradation of several cell-cycle regulators during G1 and M phase. Securin is a key APC substrate and the one whose degradation gave rise to the name APC: securin binds to and inhibits a protease termed separase, which, when released following securin degradation, cleaves proteins that hold sister chromatids together, thereby initiating anaphase.
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