News and Views
Nature Cell Biology 10, 379 - 381 (2008)
doi:10.1038/ncb0408-379
Dam1 complexes go it alone on disassembling microtubules
Melissa K. Gardner1 & David J. Odde1
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Melissa K. Gardner and David J. Odde are in the Department of Biomedical Engineering, University of Minnesota, 312 Church Street SE, 7-132 Hasselmo Hall, Minneapolis, Minnesota 55455, USA.
e-mail: oddex002@umn.edu
Abstract
Kinetochores maintain a mechanical grip on disassembling microtubule plus ends, possibly through a 16-member Dam1 ring that acts as a sliding clamp. It turns out, however, that a ring is not required for maintaining grip: individual Dam1 complexes in vitro can diffuse on the microtubule lattice and track shortening microtubule tips.
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