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Nature Cell Biology 10, 373 - 374 (2008)
doi:10.1038/ncb0408-373
Neurogenesis directed by Sirt1
Sergiy Libert1, Dena Cohen1 & Leonard Guarente1
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Sergiy Libert, Dena Cohen and Leonard Guarente are at Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
e-mail: leng@mit.edu
Abstract
Differentiation of neuronal stem cells into astrocytes or neurons is important in maintaining brain function. Oxidative stress and inflammation are now shown to bias differentiation toward astrocytes by modulating activity of the anti-ageing gene Sirt1. These findings link a longevity gene to the activity of neuronal stem cells and their response to stress.
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