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Letter

Nature Cell Biology 10, 353–360 (1 March 2008) | doi:10.1038/ncb1698

A core Klf circuitry regulates self-renewal of embryonic stem cells

Jianming Jiang , Yun-Shen Chan , Yuin-Han Loh , Jun Cai , Guo-Qing Tong , Ching-Aeng Lim , Paul Robson , Sheng Zhong & Huck-Hui Ng

Embryonic stem (ES) cells are unique in their ability to self-renew indefinitely and maintain pluripotency. These properties require transcription factors that specify the gene expression programme of ES cells.