Access

Letter

Nature Cell Biology 10, 361–369 (1 March 2008) | doi:10.1038/ncb1699

VHL loss actuates a HIF-independent senescence programme mediated by Rb and p400

Arthur P. Young , Susanne Schlisio , Yoji Andrew Minamishima , Qing Zhang , Lianjie Li , Chiara Grisanzio , Sabina Signoretti & William G. Kaelin

Germline von Hippel–Lindau tumour suppressor gene (VHL) mutations cause renal cell carcinomas, haemangioblastomas and phaeochromocytomas in humans. Mutations in VHL also occur in sporadic renal cell carcinomas.