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Nature Cell Biology 10, 255–257 (1 March 2008) | doi:10.1038/ncb0308-255
Breaking the ties that bind centriole numbers
Abstract
Armed only with the light microscope and keen skills of observation, cell biologists of the early part of the twentieth century first recognized that the centrosome is fundamental for organizing the cytoplasm and controlling chromosome dynamics during cell division. In these early investigations, centrioles, which reside at the very centre of the centrosome, gained attention because of their enigmatic autonomy — centriole number doubles from two to four in a process that is strictly coordinated with DNA replication, and then their number is reduced again as pairs of centrioles partition into daughter cells during cell division (Fig.
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