1. Héctor Peinado and Amparo Cano are in the Departamento de Bioquímica, Facultad de Medicina, Universidad Autónoma de Madrid. Instituto de Investigaciones Biomédicas "Alberto Sols" Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid. Arturo Duperier, 4, 28029 Madrid, Spain.
   e-mail: acano@iib.uam.es

Abstract

Hypoxia is a critical factor during tumour progression, regulating the expression of multiple factors implicated in tumour growth, epithelial to mesenchymal transition (EMT) and invasive cell behaviour. We now learn that the EMT inducer Twist operates under the control of hypoxia signalling in the tumour microenvironment.

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