1. Songyu Wang and Davis Ng are in the Temasek Life Sciences Laboratory and the Department of Biological Sciences, National University of Singapore, 117604 Singapore.
   e-mail: davis@tll.org.sg

Abstract

How cells decide that a protein is misfolded is a mystery. The endoplasmic reticulum integrates N-linked glycosylation into the decision as to whether a protein is misfolded. The basic strategy of glycan-based recognition, previously identified in yeast, is conserved in mammals but is expanded, possibly to accommodate a more complex client portfolio.

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