1. P. Mattson and Henriette van Praag are in the Laboratory of Neurosciences, National Institute on Aging, Intramural Research Program, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA.
   e-mail: mattsonm@grc.nia.nih.gov

Abstract

The cell adhesion molecule TAG1 has been identified as the ligand that induces -amyloid precursor protein (APP) processing and signalling, resulting in the inhibition of neurogenesis. These findings demonstrate a critical role of TAG1–APP signalling in brain development and suggest the potential involvement of TAG1 in adult neuroplasticity and pathogenesis of Alzheimer's disease.

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