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Volume 10 Issue 2, February 2008

In the Drosophila wing imaginal disc, retromer is required for Wnts to promote Wntless accumulation (in white, horizontal Wntless stripe induced by endogenous Wingless and vertical Wntless induced by ectopic Wnt).

Volume 10 Issue 2

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Editorial

  • The European Registry for Human Embryonic Stem Cells (hESCreg) adds an important global resource to the fragmented landscape of stem cell research.

    Editorial

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News & Views

  • Two studies report expression of telomeric-repeat-containing RNAs in vertebrates. This discovery challenges the long-standing notion that telomeres are transcriptionally inert.

    • Béatrice Horard
    • Eric Gilson
    News & Views

  • Nerve growth factor induces sensory neuron survival via retrograde signalling from the axon to the cell body. Local translation of the transcription factor CREB in the axon, followed by its transport to the nucleus, is involved in this process.

    • Andrew C. Lin
    • Christine E. Holt
    News & Views

  • Ena/VASP family members have a common binding interface on their EVH1 domains for FPPPP motifs in partner proteins. The finding that Tes, a protein lacking FPPPP motifs, competes specifically for the FPPPP ligand site on Mena, provides new insights into the differential regulation of Ena/VASP proteins.

    • J. Victor Small
    News & Views

  • Most chloroplast proteins are encoded in the cell nucleus, translated in the cytosol, and targeted to the organelle in a post-translational manner. Our understanding of how proteins are targeted to the outer envelope membrane of chloroplasts has been improved with the identification of a specific soluble sorting factor.

    • Jocelyn Bédard
    • Paul Jarvis
    News & Views

  • Planarian flatworms regenerate their heads and tails after amputation. It turns out that they use Wnt–β-catenin signalling to determine where the head and the tail should form.

    • Elly M. Tanaka
    • Gilbert Weidinger
    News & Views

  • Constitutively active ERK signalling stimulates cell proliferation, thereby contributing to tumorigenesis. We now learn that ERK activity induces phosphorylation and MDM2-mediated degradation of the tumour-suppressing transcription factor FOXO3a, thus gaining new information on valuable targets for human cancer therapeutic intervention.

    • Wensheng Yang
    • Nathan G. Dolloff
    • Wafik S. El-Deiry
    News & Views
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