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Letter
Nature Cell Biology 10, 211–219 (1 February 2008) | doi:10.1038/ncb1682
Membrane nanotubes physically connect T cells over long distances presenting a novel route for HIV-1 transmission
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Abstract
Transmission of HIV-1 via intercellular connections has been estimated as 100–1000 times more efficient than a cell-free process, perhaps in part explaining persistent viral spread in the presence of neutralizing antibodies. Such effective intercellular transfer of HIV-1 could occur through virological synapses or target-cell filopodia connected to infected cells.
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