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Nature Cell Biology 10, 125 - 126 (2008)
doi:10.1038/ncb0208-125

ERK and MDM2 prey on FOXO3a

Wensheng Yang1, Nathan G. Dolloff1 & Wafik S. El-Deiry1

  1. Wensheng Yang, Nathan G. Dolloff and Wafik S. El-Deiry are in the Laboratory of Molecular Oncology and Cell Cycle Regulation, Departments of Medicine (Hematology/Oncology), Pharmacology, and Genetics, The Abramson Comprehensive Cancer Center, and the Institute for Translational Medicine and Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.
    e-mail: wafik@mail.med.upenn.edu

Constitutively active ERK signalling stimulates cell proliferation, thereby contributing to tumorigenesis. We now learn that ERK activity induces phosphorylation and MDM2-mediated degradation of the tumour-suppressing transcription factor FOXO3a, thus gaining new information on valuable targets for human cancer therapeutic intervention.

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