News and Views
Nature Cell Biology 10, 118 - 120 (2008)
doi:10.1038/ncb0208-118
Facing up to Mena: Tes(ting) times for EVH1 domains
J. Victor Small1
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J. Victor Small is at the Austrian Academy of Sciences, IMBA - Institute of Molecular Biotechnology, Dr. Bohr-Gasse 3, 1030 Vienna, Vienna, A-1030, Austria.
e-mail: vic.small@imba.oeaw.ac.at
Abstract
Ena/VASP family members have a common binding interface on their EVH1 domains for FPPPP motifs in partner proteins. The finding that Tes, a protein lacking FPPPP motifs, competes specifically for the FPPPP ligand site on Mena, provides new insights into the differential regulation of Ena/VASP proteins.
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