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Letter

Nature Cell Biology 10, 1463–1469 (1 December 2008) | doi:10.1038/ncb1806

Activation of TGF-|[beta]|/activin signalling resets the circadian clock through rapid induction of Dec1 transcripts

Naohiro Kon , Tsuyoshi Hirota , Takeshi Kawamoto , Yukio Kato , Tadashi Tsubota & Yoshitaka Fukada

The circadian clock is reset by external time cues for synchronization to environmental changes. In mammals, the light-input signalling pathway mediated by Per gene induction has been extensively studied.