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Out of the jaws of death: PRMT5 steers p53

Nature Cell Biology volume 10, pages 1389–1390 (2008)Cite this article

The tumour suppressor p53 triggers either cell-cycle arrest or apoptosis. Now, arginine methylation joins a panoply of other post-translational modifications that regulate p53. PRMT5 mediates p53 methylation, which disposes the cell to arrest rather than death.

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Figure 1: PRMT5 regulation of p53.

References

  1. Levine, A. J., Momand, J. & Finlay, C.A. Nature 351, 453–456 (1991).

    Article  CAS  Google Scholar 

  2. Laptenko, O. & Prives, C. Cell Death Differ. 13, 951–961 (2006).

    Article  CAS  Google Scholar 

  3. Aylon, Y. & Oren, M. Cell 130, 597–600 (2007).

    Article  CAS  Google Scholar 

  4. Burley, S.K. Structure 15, 789–792 (1994).

    Article  Google Scholar 

  5. Kruse, J.P. & Gu, W. Cell 133, 930 (2008).

    Article  CAS  Google Scholar 

  6. Holmberg, C.I., Tran, S.E., Erksson, J.E. & Sistonen, L. (2002). Trends Biochem Sci. 27, 619–627.

    Article  CAS  Google Scholar 

  7. Prives, C. & Manley, J.L. Cell 107: 815–818 (2001).

    Article  CAS  Google Scholar 

  8. Huang, J. & Berger, S.L. Curr. Opin. Genet. Dev. 449, 105–108. (2008).

    Google Scholar 

  9. McBride, A.E. & Silver, P.A. Cell 106, 5–8 (2001).

    Article  CAS  Google Scholar 

  10. Jansson, M. et al. Nature Cell Biol. 10, 1431–1439 (2008).

    Article  CAS  Google Scholar 

  11. Toledo, F. & Wahl, G.M. Nature Rev. Cancer 6, 909–923 (2006).

    Article  CAS  Google Scholar 

  12. Tang, Y., Zhao. W., Chen, Y., Zhao, Y. & Gu, W. Cell 133, 612–626 (2008).

    Article  CAS  Google Scholar 

  13. Chen, D. et al. Science 284, 2174 (1999).

    Article  CAS  Google Scholar 

  14. An, W., Kim, J. & Roeder, R.G. Cell 117, 735–748 (2004).

    Article  CAS  Google Scholar 

  15. Barlev, N. et al. Mol. Cell 8, 1243–1254 (2001).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Shelley Berger is at The Wistar Institute, Gene Expression & Regulation Program, 3601 Spruce Street, Room 201, Philadelphia, Pennsylvania 19104, USA. berger@wistar.org,

    Shelley L. Berger

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  1. Shelley L. Berger
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Berger, S. Out of the jaws of death: PRMT5 steers p53. Nat Cell Biol 10, 1389–1390 (2008). https://doi.org/10.1038/ncb1208-1389

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