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Nature Cell Biology 10, 1389 - 1390 (2008)
doi:10.1038/ncb1208-1389
Out of the jaws of death: PRMT5 steers p53
Shelley L. Berger1
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Shelley Berger is at The Wistar Institute, Gene Expression & Regulation Program, 3601 Spruce Street, Room 201, Philadelphia, Pennsylvania 19104, USA.
e-mail: berger@wistar.org
Abstract
The tumour suppressor p53 triggers either cell-cycle arrest or apoptosis. Now, arginine methylation joins a panoply of other post-translational modifications that regulate p53. PRMT5 mediates p53 methylation, which disposes the cell to arrest rather than death.
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