1. Andrew M. Fry is in the Department of Biochemistry, University of Leicester, Leicester LE1 9HN, UK.
   e-mail: amf5@le.ac.uk
2. Hiroyuki Yamano is at the Marie Curie Research Institute, Oxted RH8, 0TL, UK.
   e-mail: h.yamano@mcri.ac.uk

Abstract

The spindle assembly checkpoint is crucial for maintaining genome integrity in dividing cells by preventing premature chromosome segregation. Degradation of the APC/C activator Cdc20 seems to be an essential and conserved mechanism to maintain this checkpoint in the presence of chromosomes that are not attached to the mitotic spindle.

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