News and Views
Nature Cell Biology 10, 1385 - 1387 (2008)
doi:10.1038/ncb1208-1385
Under arrest in mitosis: Cdc20 dies twice
Andrew M. Fry1 & Hiroyuki Yamano2
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Andrew M. Fry is in the Department of Biochemistry, University of Leicester, Leicester LE1 9HN, UK.
e-mail: amf5@le.ac.uk -
Hiroyuki Yamano is at the Marie Curie Research Institute, Oxted RH8, 0TL, UK.
e-mail: h.yamano@mcri.ac.uk
Abstract
The spindle assembly checkpoint is crucial for maintaining genome integrity in dividing cells by preventing premature chromosome segregation. Degradation of the APC/C activator Cdc20 seems to be an essential and conserved mechanism to maintain this checkpoint in the presence of chromosomes that are not attached to the mitotic spindle.
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