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Letter
Nature Cell Biology 10, 1356–1364 (1 November 2008) | doi:10.1038/ncb1795
Scaffolding function of PAK in the PDK1|[ndash]|Akt pathway
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Abstract
Many extracellular signals stimulate phosphatidylinositol-3-kinase, which in turn activates the Rac1 GTPase, the protein kinase Akt and the Akt Thr 308 upstream kinase PDK1. Active Rac1 stimulates a number of events, including substrate phosphorylation by a subgroup of the PAK family of kinases.
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