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Letter

Nature Cell Biology 10, 1318–1323 (1 November 2008) | doi:10.1038/ncb1790

The TBP|[ndash]|PP2A mitotic complex bookmarks genes by preventing condensin action

Hongyan Xing , Nathan L. Vanderford & Kevin D. Sarge

To maintain phenotypes of cell lineages, cells must 'remember' which genes were active before mitosis entry and transmit this information to their daughter cells so that expression patterns can be faithfully re-established in G1. This phenomenon is called gene bookmarking.