1. Andrea H. Brand is in the Gurdon Institute and Department of Physiology, Development and Neuroscience, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN UK.
   e-mail: ahb@mole.bio.cam.ac.uk

Abstract

The balance between proliferation and differentiation is essential not only for the generation and maintenance of tissues, but also to prevent uncontrolled cell division and tumorigenesis. The mitotic kinase Aurora A coordinates cell-cycle events and asymmetric division by regulating localization of the cell fate determinant Numb through remodelling of the conserved PAR polarity complex.

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