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Letter
Nature Cell Biology 10, 1208–1216 (1 October 2008) | doi:10.1038/ncb1781
Jade-1 inhibits Wnt signalling by ubiquitylating |[beta]|-catenin and mediates Wnt pathway inhibition by pVHL
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Abstract
The von Hippel–Lindau protein pVHL suppresses renal tumorigenesis in part by promoting the degradation of hypoxia-inducible HIF-α transcription factors; additional mechanisms have been proposed. pVHL also stabilizes the plant homeodomain protein Jade-1, which is a candidate renal tumour suppressor that may correlate with renal cancer risk.
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