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Letter

Nature Cell Biology 10, 1190–1198 (1 October 2008) | doi:10.1038/ncb1779

d-Asb11 is an essential mediator of canonical Delta|[ndash]|Notch signalling

Sander H. Diks , Maria A. Sartori da Silva , Jan-Luuk Hillebrands , Robert J. Bink , Henri H. Versteeg , Carina van Rooijen , Anke Brouwers , Ajay B. Chitnis , Maikel P. Peppelenbosch & Danica Zivkovic

In canonical Delta–Notch signalling, expression of Delta activates Notch in neighbouring cells, leading to downregulation of Delta in these cells. This process of lateral inhibition results in selection of either Delta-signalling cells or Notch-signalling cells.