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Letter

Nature Cell Biology 10, 1181–1189 (1 October 2008) | doi:10.1038/ncb1778

Targeting of the F-actin-binding protein drebrin by the microtubule plus-tip protein EB3 is required for neuritogenesis

Sara Geraldo , Umme K. Khanzada , Maddy Parsons , John K. Chilton & Phillip R. Gordon-Weeks

Interactions between dynamic microtubules and actin filaments (F-actin) underlie a range of cellular processes including cell polarity and motility. In growth cones, dynamic microtubules are continually extending into selected filopodia, aligning alongside the proximal ends of the F-actin bundles.