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Nature Cell Biology 10, 1129 - 1130 (2008)
doi:10.1038/ncb1008-1129
Stressed out? Make some modifications!
Angela Hilliker1 & Roy Parker1
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Angela Hilliker and Roy Parker are in the Department of Molecular and Cellular Biology and Howard Hughes Medical Institute, University of Arizona, Tucson, AZ, 85721-0106, USA.
e-mail: rrparker@u.arizona.edu
Abstract
Stress granules and processing bodies are related mRNA-containing granules implicated in controlling mRNA translation and decay. A genomic screen identifies numerous factors affecting granule formation, including proteins involved in O-GlcNAc modifications. These results highlight the importance of post-translational modifications in translational control and mRNP granule formation.
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RESEARCH
A functional RNAi screen links O-GlcNAc modification of ribosomal proteins to stress granule and processing body assemblyNature Cell Biology Letter (01 Oct 2008)
MK2-induced tristetraprolin:14-3-3 complexes prevent stress granule association and ARE-mRNA decayThe EMBO Journal Article (24 Mar 2004)
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